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Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment

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Le flux lysosomal du cholestrol libre (FC) est essentiel la production d'oxystrols qui dclenche l'activation du LXR (Liver X receptor, entranant une augmentation de l'expression du transporteur ABCA1 et de l'efflux de cholestrol pour liminer le cholestrol des cellules (LAL (Lysosomal Acid Lipase) Promotes Reverse Cholesterol Transport In Vitro and In Vivo 2018)

In severe MC with multisystem involvement, immunosuppressive therapy is recommended with rituximab-based regimens with or without plasmapheresis prior to initiation of antiHCV therapy