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Subsequently, divalent metal transporter 1 (DMT1) transports Fe + into the cytoplasm ( + ) can participate in the Fenton reaction, generating hydroxyl radicals (OH), which initiate and propagate lipid peroxidation chain reactions, thereby acting as one of the key triggers of ferroptosis ( + in ferritin, a cytosolic iron storage protein

AAPS J (2017) 19(6):156475

However, various physicochemical and biological factors within the IVD microenvironment, such as pH, osmotic pressure, hypoxia, inflammation, and mechanical stress, severely compromise the survival and function of transplanted cells

When someone exhibits bravery, we say they have guts and when someone is upset, they are gutted. From being an idiom, to a second brain, or just digesting our lunch, guts are super important