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for example, TNF- has a significant proviral replicative effect on JC polyomavirus in neuronal tumour cells 40 and has significant antiviral effects on cytomegalovirus CSFV 41 , CMV 42 and herpesvirus type I (HSV-1) 43

Eosinophil-derived MMP-9 is found in basal cell and squamous cell carcinomas95,96 and in bullous pemphigoid lesions.97 MMP-9 cleaves type XVII collagen (BP 180), a transmembrane molecule of the epidermal hemidesmosome, likely contributing to or causing basement membrane zone separation in bullous pemphigoid

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