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Furthermore, methotrexate (MTX), the immunosuppressant commonly used for the treatment of RA, has been demonstrated that could reduce inflammation and subsequent tissue damage by inhibiting MAA-adducts formation and scavenging superoxide in RA [108]

Since the mechanism of induction of tumours by acetaldehyde has not been well studied, lifetime cancer risk has also been estimated on the basis of a default model (i.e., linearized multistage) (WHO, in press)

Furthermore, this finding provides a possible explanation for the reported mild hepatotoxicity associated with the clinical use of bile acid sequestrants in human patients