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And, in a salient case study, an 8-fold spike in serum GABA and 13-fold increase in glutamate preceded the appearance of GAD antibodies by 2.5 years (121)

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A 2018 meta-analysis of 17 randomized controlled trials found that ALA supplementation significantly reduced total cholesterol, LDL-C, and triglycerides, though it had no consistent effect on HDL-C