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This increases the risk that: Products may be contaminated or mislabeled Adverse events may not be monitored or reported Patients may be misled about efficacy 4

The authors propound that deficient islet GABA signaling/content may contribute to the hyper-glucagonemia of T2D which again reinforces a role for GABA-based therapeutics

The underlying mechanism is that angiotensin II binds to angiotensin II type 1 (AT1) receptor and then activates JAK/STAT signaling to induce IL-6 production