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N -acetylcysteine (NAC) additional mechanisms in addition to replenishment of GSH: Evidence Analgesia Acetaminophen versus Placebo for Treatment of Osteoarthritis Acetaminophen versus Nonsteroidal Antiinflammatory Drugs for Treatment of Osteoarthritis Acetaminophen plus Codeine versus Placebo postoperative patients demonstrated significant differences for obtaining at least 50% pain relief over 4 to 6 hours, with a number needed to treat (NNT) of 2.2 for high doses (800 to 1000 mg acetaminophen plus 60 mg codeine) and smaller effect sizes for medium and smaller doses (as low as 325 mg acetaminophen with 30 mg codeine)

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Poor responders or those with particularly stubborn chronic conditions may benefit from longer treatment phases before breaks

Kilberg, M