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In adipose tissue (where NNMT is highly expressed), inhibition activates the polyamine flux pathway and shifts adipocytes toward a 'beige' phenotype with elevated energy expenditure

(8) Ulanovskaya OA, et al

NNMT (Nicotinamide N-Methyltransferase) Inhibition Potently and selectively binds to the nicotinamide binding site of NNMT, blocking the methylation of nicotinamide using SAM 4