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Paired-end sequencing data were processed with Cell Ranger ATAC (v.1.0.1) by the Columbia University Single Cell Analysis Core

The Cell Code A Cellular Medicine Perspective on Health, Aging, and Disease Cell Code is a structured walk through ten core molecular pathways that shape Cellular Medicine

doi: 10.1161/ATVBAHA.117.310605

Weight loss trajectory was still accelerating Phase 1 (oral): 10.4-13.1% weight loss at 12 weeks depending on dosing regimen vs 1.2% placebo Phase 2 (T2D): SC amycretin showed up to 14.5% weight loss and HbA1c reductions up to 1.8% at 36 weeks