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3.1.1 pH-responsive conjugate-based nanomedicines During RA, the lesions create a acidic environment with a pH of up to 6.0

Up to date, it is established that GHK-Cu can: Tighten loose skin and reverse thinning of aged skin Repair protective skin barrier proteins Improve skin firmness, elasticity, and clarity Reduce fine lines, depth of wrinkles, and improve the structure of aging skin Smooth rough skin Reduce photodamage, mottled hyperpigmentation, skin spots, and lesions Improve overall skin appearance Stimulate wound healing Protect skin cells from UV radiation Reduce inflammation and free radical damage Increase hair growth and thickness, enlarge hair follicle size Dr

At pH 5.7, the histidine imidazole (pKa ~6.0) remains predominantly deprotonated and available for copper coordination

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