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This study also indicates that Odh and Pdh rather than the ETC Complexes may serve as the central hub for ROS signaling from mitochondria to the rest of the cell and thus may be an important pharmacological target for treatment of various diseases

ODriscoll histological assessment Histological findings ( n = 8 at each time point) for each section were evaluated and scored by three investigators according to ODriscoll histological grading parameters (cell morphology, matrix staining, structural integrity, thickness/defect filling, osteochondral junction, adjacent bonding, basal integration, cellularity, clustering/distribution, and adjacent cartilage) to quantitatively evaluate the extent of cartilage repair based on the criteria of predominant tissue type, structural properties, freedom from degenerative changes in the neighboring cartilage, and freedom from cellular changes of degeneration [26]

Wolfe has broad research and clinical interests in abnormal child and adolescent psychology, with a special focus on child abuse, domestic violence, and developmental psychopathology, and he has published widely on these topics