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The maintenance frequency approach represents hybrid strategy where initial intensive treatment (daily application for 3-6 months) establishes improvements, then reduces to maintenance schedule (2-3 times weekly or every other day) rather than complete discontinuation

Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice

Similarly, and for NA, no statistical significance was found in ROS synthesis between control and test samples

Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload